[5] She earned a master's degree in child development and psychology, with a specialty in instructional technology and media,[6][7] from Columbia University.

[10] Santomero worked as a researcher for Nickelodeon in the early 1990s,[10] when the network was looking to create a new television show for preschoolers.

"[12] Santomero served as executive producer and head writer, and designed the show's research and curriculum.

In September 2012, Daniel Tiger's Neighborhood, for which Santomero is creator,[13] executive producer and head writer, debuted on PBS.

[16][17] Angela authored Preschool Clues - Raising Smart, Inspired and Engaged Kids in a Screen-Filled World (Touchstone 2018)[18] with co-author Deborah Reber, and authored Radical Kindness - The Life-Changing Power of Giving and Receiving (HarperCollins Publishers 2019)[19] with foreword by Deepak Chopra.