[1] She has owned and operated VIVO Cafe for over 25 years, established Eagle Waves Radio, and was elected Deputy Chairperson of the City of Sydney Economic Development and Business Sub-Committee.

[2][3][4] Angela makes regular public and media appearances as an advocate for small businesses in the City of Sydney.

At the 2021 local government elections, Vithoulkas ran as part of the Small Business Party but was unsuccessful in her bid for a third term on the council.

[18] In 2012, Vithoulkas was approached by real estate agent and former campaign manager to Lord Mayor Clover Moore, Barry Goldman to run for public office as part of the Living Sydney Independent party.

[22] In 2014, Vithoulkas left the Living Sydney party citing its links to the liquor and gambling industry publicly.

[23] The Sydney Matters Independent team also notably included Chinese immigration lawyer Grace Zou, founder of online publication start-up Daily Mat Beeche, and fitness blogger Lorraine Chung.

[29] In 2014, the NSW Government introduced legislation, coined the lockout laws, aimed at decreasing alcohol related violence following a series of assaults in Sydney's King's Cross district.

In early August 2017, Vithoulkas hosted a business resident action meeting for those affected by the light rail.

In late August 2017, after 2 years of campaigning, the NSW State Government announced it would award rent relief to businesses that were negatively affected by Light Rail construction.

[40] In October 2017, Vithoulkas announced plans to challenge for a seat in State Parliament after establishing the Small Business Matters party.

I could see that getting through to State Government after the fact is the hardest job of all," and that it was time to "take it up a notch in the upper house and keep the bastards honest".

Small Business Matters surpassed 1000 members on 6 November 2017, making it eligible to qualify and register as a political party.