She debuted as a child actress in the Golden Age of Mexican Cinema in films such as Pecado (1951), Una mujer decente (1951) y Mi esposa y la otra (1954).

During the 1960s, she became a teen idol in Mexico thanks to her telenovelas and films, along with her musical career with compositions by Armando Manzanero that made her known as a rock and roll and pop ballad singer.

She sang in her two next movies, 2 Caras Tiene el Destino ("Destiny Has Two Faces") and Los Gavilanes (The Hawks) with superstar Pedro Infante, who told her she would be a great actress, because she spoke with her eyes, as he did.

[citation needed] With Chucho Ferrer in the roles of musical director and arranger, Angélica María covered the Barbara Ruskin song, "Gentlemen Please" which was released on RCA as "Los años locos".

The single Tú sigues siendo el mismo ("You are still the same one") sold one million copies in the United States alone, and has since then been performed by dozens of other singers.

In 1986, she starred in Herencia Maldita ("Cursed inheritance") singing the theme-song and releasing an album called "El Hombre de Mi Vida".

The same year Angélica impressed the audience in the theater play La mama nos quita los novios, sharing credits with Julio Alemán.

From August 2012 to May 2013, Angelica Maria acted as 'Amalia Mendoza' in Qué Bonito Amor, starring along Danna García, Jorge Salinas, Juan Ferrara, Evita Muñoz "Chachita", etc.

[citation needed] In 1980, she recorded her 28th album and created the show La historia del cine ("The history of cinema") in which she sang, danced, and performed various characters.

That same year she recorded another album with Juan Gabriel and starred in El hogar que yo robé ("The home I stole") that would be remade in the 1990s as La usurpadora.

In 2006, joined again the show "Los Grandes del Rock" making tours throughout Mexico, and reteamed with her daughter Angelica Vale for the telenovela La fea mas bella (The Prettiest Ugly Girl).

The series was a ratings smash, and in 2009 they acted again as a mother and daughter in the second season of Mujeres asesinas (Murderous women) in the episode Julia, encubridora.

In 2012 Angelica joined Alberto Vázquez and César Costa in the show TR3S, performing tours throughout Mexico, delighting their Mexican & Latin audiences with their singing voices, up until nowadays.

Between June 2013 and 2014, Angelica formed part of the jury of the Spanish-language version of The X Factor, which was broadcast starting that summer on MundoFox in the United States.