Angelo studied at the Accademia di Brera in Milan under Giuseppe Bertini.
Angelo would hold a teaching position at the academy until his death.
He helped decorate with frescoes the Palazzo della Borsa, Casa Verdi, and the facade of San Giovanni Battista at Induno Olona.
At the former Abbey of Morimondo is now the Civico museo Angelo Comolli, displaying some of his works and designs.
Note: In 1790, a different Angelo Comolli published a putative original biography of Raphael, supposedly predating Vasari.