Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue cancer that affects children and young adults.

It is characterized by cystic blood-filled spaces and composed of histiocyte-like cells.

It often simulates a vascular lesion, and was initially described as doing this.

[1] AFH typically has a chromosomal translocation involving the ATF1 gene -- t(12;16) FUS/ATF1 or t(12;22) EWS/ATF1.

[2] This oncology article is a stub.