Lee created an initial series of animations in the late 1990s, and worked with the Asian American channel Mnet for a 12-episode season released in 2014.

When Lee was a student at the University of California, Berkeley in 1994, she attended Spike and Mike's Sick and Twisted Festival of Animation.

She walked out mad at a series of ethnic jabs and drew her own animations that night, using Crayola markers and then video-editing equipment at school to complete her first episode.

[6][4] Kevin Thomas, reviewing for the Los Angeles Times, called Angry Little Asian Girl "scabrously funny", saying "Lee is a minimalist, using simple Magic Marker drawings, but boy does she have plenty to say.

Her diminutive grade-school-age heroine unleashes a torrent of foul language whenever she's offended--and this happens a lot--by any behavior that strikes her as racist or discriminatory (or male chauvinist).

"[4] Also in 1998, Lee launched a website for the animated series and started selling merchandise,[7] which now covers an extensive range of products.

[citation needed] Once the works and merchandise began to be successful, Lee sought to make a full TV version, but met resistance from executives.

"[13] On 25 December 2014, a 12-episode version of Angry Little Asian Girl was released, with Mnet broadcasting all 12 episodes in a three-hour block.