Lee made a guest appearance in the first episode of Season Four of HBO's Curb Your Enthusiasm, playing an angry Asian woman, who launches a physical and verbal attack on star Larry David after he suggests Tang is a common Chinese name.

[2] That night, Lee stayed up drawing with typing paper and Crayola markers, and a video camera[2] and made the first episode "Angry Little Asian Girl, the First Day of School.

[4] These episodes, like the first, use foul language and shocking imagery to bring attention to issues surrounding the intersection of being Asian and a woman.

With the newly created characters, and an umbrella name of "Angry Little Girls" Lee turned her work into a weekly comic strip self-published on her website www.angrylittlegirls.com.

Lee added characters of diverse ethnicities and backgrounds to increase her strip's public and commercial appeal.