Her sister Ankhesenpepi I was also married to King Pepi I and her brother Djau served as vizier.

There are indications that Ankhesenpepi II served as a regent for her son in those early years of his reign.

[4] She is also mentioned together with her sister on their brother's stela in Abydos, at her pyramid and in that of her daughter-in-law Neith.

[3] Her titles as queen were: Great one of the hetes-sceptre (wrt-hetes), She who sees Horus and Seth (m33t-hrw-stsh), Great of Praises (wrt-hzwt), King's Wife of Mennefer-Meryre (hmt-niswt-mn-nfr-mry-r`), King's Wife, his beloved (hmt-nisw meryt.f), God's Daughter (s3t-ntr), This Daughter of a God (s3t-ntr-wt), Attendant of the Great One (khtt-wr), Companion of Horus (tist-hrw), Companion of Horus (smrt-hrw).

In 1999 and 2000, excavation work at her Saqqara funerary temple uncovered several stone blocks inscribed with a previously unknown royal title for her: Since the temple was constructed under Pepi II because it makes a reference to king Pepi II, this shows that Merenre married Queen Ankhesenpepi II after Pepi I died.

The texts in the burial chamberrefer to her as a queen mother, hence the construction of her pyramid dates to the reign of her son.