2310 BC) was a queen consort during the Sixth Dynasty of Egypt.

Ankhesenpepi was a daughter of the female vizier Nebet and her husband Khui, nomarch of Abydos.

Ankhesenpepi's sister was Ankhenespepi II, and her brother was Vizier Djau.

[1] Both sisters – Ankhesenpepi I and II – were married to King Pepi I whose throne name was Meryre; their name was probably taken when the marriage took place, since it means "Her life belongs to Pepi/Meryre".

Both queens gave birth to successors of Pepi: the son of Ankhesenpepi I was Nemtyemsaf I, who ruled only for a few years; the son of Ankhenespepi II was Pepi II, who succeeded after Nemtyemsaf's death.