She appeared in the drama series The Way We Were, for which she won a Golden Bell Award for Best Supporting Actress.

[4] Hsu attended the Hwa Kang Arts School in Taipei where she was classmates with Rainie Yang and Alien Huang.

Friends call her by her middle name, Ann, which is also the English name listed on her agency's profile webpage.

[8] The 40-minute-long microfilm (four episodes of 10 minutes each) tells the story of two vacationers unexpectedly meeting and finding love with each other through a series of adventures during their stay at Resorts World Sentosa.

In 2015, Hsu starred in the horror film The Tag-Along, playing a smart and independent radio DJ who has a fear of commitment in relationships.

[14] On 10 December 2021, Hsu announced her marriage to Roy Chiu, her co-star in the 2021 romance film Man in Love.