[1] It is a major thoroughfare, linking as a four-lane one-way street the suburb of Fortitude Valley in the northeast with the Riverside Expressway in the southwest; house numbers run the opposite direction.

Parks and buildings along Ann Street include the State Law Building, Central Railway Station, Brisbane City Hall, King George Square, King George Central, and also ANZAC Square and the Shrine of Remembrance (both of which commemorate Australia's and New Zealand's war dead).

The now demolished Canberra Hotel (1929–1987) was located on the corner of Ann and Edward Streets.

[2] There is also a memorial service held each year on Armistice Day (11 November) and wreaths are again laid at the eternal flame.

[7][8][9][10] The Canberra Hotel, erected by the Queensland Prohibition League on the western corner of Ann and Edward Streets, was opened on 20 July 1929 and demolished in 1987.