Margaret Street is a major road in the central business district of Brisbane.

The street is one of a number that were named after female members of the royal family shortly after the penal colony was settled.

Part of the Queen's Wharf, Brisbane project is being built on Margaret Street.

Another prominent building on the road is the skyscraper called Mineral House containing offices.

In 1885 the Brisbane Hebrew Congregation built a synagogue on Margaret Street, which still stands today, largely unaltered.