Anna Maria of Mecklenburg-Schwerin (1 July 1627, in Schwerin – 11 December 1669, in Halle) was a German noblewoman, a member of the House of Mecklenburg and by marriage Duchess of Saxe-Weissenfels.

The wars involving Mecklenburg forced her father to send Anna Maria and her two older brothers, Christian Louis and Karl, first to Sweden and shortly afterwards to Denmark, to the court of Dowager Queen Sophia (born Duchess of Mecklenburg-Güstrow).

In 1629 Anna Maria was sent to Saxony with Dowager Electress Hedwig, to the latter's dower state, Castle Lichtenberg near Prettin, where she was educated.

On 23 November 1647, in Schwerin, Anna Maria married Augustus, second surviving son of Johann Georg I, Elector of Saxony, and moved with her husband to Halle, the main city of his domains as Administrator of the Archbishopric of Magdeburg.

On 22 April 1657 her husband, by the terms of his father's will, received the towns of Weissenfels and Querfurt as his own Duchy, and hence Anna Maria became Duchess consort of Saxe-Weissenfels.