Sophia of Saxe-Weissenfels (also: Sophie; 23 June 1654 in Halle an der Saale – 31 March 1724 in Zerbst) was a member of the Albertine branch of the House of Wettin, and a princess of Saxe-Weissenfels and Querfurt by birth and by marriage Princess of Anhalt-Zerbst.

She was named after her paternal great-grandmother, Sophie of Brandenburg, Electress of Saxony.

She married on 18 June 1676 in Halle her first cousin once removed, Charles William, a son of her paternal first cousin Sophie Augusta of Holstein-Gottorp and John VI, Prince of Anhalt-Zerbst.

Unlike most royal couples of the era, Charles William and Sophia shared a bedroom in their new baroque palace.

After the destruction of the castle in 1945, the remains of the damaged coffins were transferred back to St. Bartholomew.