[1] Pyle is the president of the RNA Society,[2] the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section[3] at the National Institutes of Health.
[4] But it wasn't until after earning her bachelor's degree from Princeton University that she committed to a career in chemistry.
She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA.
Specifically, she was successful in crystallizing and solving the structure of a group IIC intron from the bacterium Oceanobacillus iheyensis[5] and moves through the stages of splicing.
[6] Pyle's research may be helpful in drug development as RNA's tertiary structure could provide insight into druggable biomolecules.