[3] Nekhames joined the studio of the Vienna State Opera in 2020, performing roles such as Musetta in Puccini's La Bohème, Madame Herz in Mozart's Der Schauspieldirektor, and Olympia in Offenbach's Les contes d'Hoffmann.
In November 2023, She appeared in the "fiercely demanding"[5] dual role of Venus and Gepopo in Ligeti's Le Grand Macabre, conducted by Thomas Guggeis.
[6][7] A reviewer described her "coloratura acrobatics" as almost unbelievable,[7] while another wrote: "Anna Nekhames in a double role almost seems to go beyond the vocal limits.
"[8] A critic from Musik Heute mentioned her among the "most exciting singers" of the performances, noting that she broke all limits.
[9] She appeared as Fauno in Mozart's early work Ascanio in Alba at the Bockenheimer Depot in December 2023.