Since the 1980s, Vissi began a nearly exclusive collaboration with songwriter Nikos Karvelas, to whom she was married from 1983 to 1992 and had one child with, resulting in one of the most successful music partnerships in the nation's history.

She landed her biggest commercial success with Fotia (1989), followed by the double Kravgi (2000), which became the eighth best-selling album of all time in terms of units,[2] while five others – Kitrino Galazio (1979), I Epomeni Kinisi (1985), Klima Tropiko (1996), Travma (1997), and Antidoto (1998) – have also achieved six figure sales.

She has a large number of successful singles most of which have become classics, including "Inai Kati Stigmes", "Tha Borousa", "Dodeka", "Methismeni Politia", "Oso Exo Foni", "Pragmata", "Agapi Ipervoliki", "Psihedelia", "Ta Mathitika Hronia", "Treno", "Stin Pira", "Atmosfaira Ilektrismeni" , "Gkazi" and many many more.

[14] She would eventually appear with a number of well-known Greek singers, such as George Dalaras, Haris Alexiou, and Vasilis Papakonstantinou, in the famous nightclubs of Plaka, in Athens.

The English version of "Mono i agapi", released as a 7-inch single in 1982, titled "Love Is A Lonely Weekend" and its B-side "I'm Gonna Be A Fool for You" remain unreleased on CD.

[16] The following year her seventh album Kati Simveni ("Something Is Happening") was released which included one of her most famous songs, titled "Dodeka" ("Twelve (O'Clock)") and reached gold status selling 80.000 units.

On New Year's Eve, by invitation of the Mayor of Athens, she performed in the Parliament Square in front of more than 20,000 people, an event which was broadcast on TV all over Greece and Cyprus.

This performance was part of a series of events hosted by the Virgin Megastore, promoting some of the world's biggest stars, with Vissi being the only Greek singer to receive this honour.

Followed by a short break from music, in April 2000 Vissi performed at London's Royal Albert Hall, at the so-called "millennium show," singing in front of people from Sony International, marketing managers from Europe, and fans from the United Kingdom.

[citation needed] In September 2000, she gave a charity concert at the GSP Stadium in Nicosia, in front of 12,000 people, with ONE and a group of dancers from Sony International.

[24] A week after its release in Greece, the album reached gold status (20,000+ copies), while Australia, South Africa, Spain, Italy, France, Germany, Turkey, Finland, Norway, and Asia started to promote it with little success.

[2] Some months later, she started appearances with Garbi and ONE at "Fever",[29] while she accepted the invitation of the Mayor of Athens to perform in the Parliament Square, at the celebrations of the 2001 New Year's Eve.

On 6 June 2001, she was the main singer in a production in Bucharest (Unirii square, nearby river Dambovitei) along with the No Smoking band and the cinema director and producer Emir Kusturica.

[30] Three months later, on 5 September 2001, she gave a concert in Cyprus (GSP Stadium), singing in front of more than 18,000 viewers, for more than three hours where she was awarded for the seven-times platinum Kravgi.

[32] The play, which was staged at Pallas Theatre in Athens, it was written by Karvelas, directed by Giannis Kakleas and was accompanied by a symphony orchestra conducted by Giorgos Niarhos.

The production and Vissi's performance was praised by critics, although some of them found it hard to accept that the biggest pop star of Greece was giving the audience such a well made artistic spectacle.

In May 2004, she went on a small tour in England and the United States,[36] with Labis Livieratos (with whom she collaborated in the early 1990s), while in July, her album Paraksenes Eikones was re-released with a bonus CD single called Remixes 2004, which went gold.

[citation needed] In July 2005, Vissi returned to Greece and released "Call Me" as a CD single by Sony BMG, along with a new English-language song titled "Lie".

[43] She also visited Malta, Cyprus, Albania, Serbia & Montenegro, Romania, Spain, Netherlands, Sweden, Bosnia & Herzegovina, Belgium, and ended her tour on 10 May 2006 in Israel.

[43] Euro Edition also contains the three other Greek Eurovision Preselection songs: "Beautiful Night", "Who Cares About Love" and "Welcome to the Party", which has entered the playlist of American satellite radio station "Sirius Beat".

[7][22] Although this was partially due to hardships faced by the Greek music industry including piracy, the 2007–2008 financial crisis,[64] and changing musical tastes,[65] leading to a general decline of the laiko-pop scene and image-based singers,[22] in an article about the "golden trio" of Greek pop, consisting of Vissi, Despina Vandi, and Sakis Rouvas, Anna Vlavianou of To Vima noted Vissi as having "the most vociferous" decline of the group.

She cited several reasons for this, such as Vissi's unsuccessful result at Eurovision and long absences from Greece in pursuit of a career abroad at a relatively advanced age, leading to her losing a portion of her established Greek fanbase.

[67] Vissi had originally planned to start appearances at "Athinon Arena" in February 2009, as part of her comeback and for promotion of the new album,[68] however, she decided to hold a concert in Athens during the summer, instead.

[citation needed] Vissi started appearances at "Athinon Arena" on 6 November 2009 with Greek band Ble, Yiorgos Sambanis, Mario, Vera Boufi, Elissavet Spanou, Michalis Zeis and DJ Dim Trik.

[107] On 12 November, Vissi was awarded by Hellenic Charity Ball who recognised the brightest arts and entertainment luminaries in the Greek-American community.The ceremony take place in San Francisco.

[126] [131] On 1 April 2013, after the economic crisis in Cyprus, Anna Vissi among other 49 artists appeared in Nicosia in a concert with the aim to help people in need by requesting clothes, food and medicine instead of tickets.

On 14 November the main cast of I Kampanes Tou Edelweis was announced and included Giannis Smasiaris, Nikolaos Karagiaouris, Thanasis Alevras, Emilios Stamatakis and Tania Tripi.

[178] The Larnaca concert lasted over four hours[179] and featured guest performances by her sister Lia Vissi and artists including Helena Paparizou, Konstantinos Argyros, Katy Garbi, and Paola.

During the event, the mayor of Larnaca, Andreas Vyras, presented Vissi with the "Golden Key" of the city, the highest local honor, which had not been awarded to anyone else in seven years.

[192] From September to November 2024, Anna Vissi performed at the "Barbarella" nightclub in Thessaloniki every Friday and Saturday,[193] before returning to her regular base, "Hotel Ermou", on December 6.