[1] Euphrosyne was the daughter of Andronikos Kamateros, a high-ranking official who held the titles of megas droungarios and pansebastos and his wife, an unknown Kantakouzene.

[4] Intelligent, determined, skilled in communication and organization, she had a talent for politics, and virtually ruled the Empire in the name of Alexios III, who had a reputation for being concerned primarily with pleasure and idle pursuits.

[5] She issued commands herself and even altered Alexios' decrees when it suited her, and secured the recall of the capable minister Constantine Mesopotamites.

Her own brother, Basil Kamateros, and her son-in-law, Andronikos Kontostephanos, possibly driven by anger at her apparent curtailing of overall familial power, accused Euphrosyne of adultery with one of her ministers, a nobleman named Vatatzes.

Euphrosyne and Alexios III fled across Greece to Thessalonica and Corinth, but were finally captured by Boniface of Montferrat and imprisoned.