Her mother, Cynthia Alfonsi, is the regional coordinator of the women's organisation of Forza Italia since the 1990s, and Annagrazia was attended in the party's miniclub in Rome.

Thanks to the election of Gianni Alemanno as mayor of Rome in 2008, she took his place in the Parliament at the age of 26, becoming the youngest Italian MP.

[1] On 17 December 2010, she was appointed coordinator of Young Italy, the youth branch of the People of Freedom.

In the 2018 parliamentary elections, she was re-elected to the Chamber of Deputies, in the uninominal college of Rome-Castel Giubileo, supported by the centre-right coalition.

On 11 November 2018, she left the leadership of the youth movement of Forza Italia to Stefano Cavedagna.