The journal's final years saw papers describing several experiments on syphilis, including one where Cazenave claimed to have inoculated himself with the disease.

Annales des Maladies de la Peau et de la Syphilis was established in 1843 by the French dermatologist Pierre Louis Alphée Cazenave, who had trained under Jean-Louis Marie Alibert at the Hôpital Saint-Louis.

[7] It received little attention unlike the experiments of Johann von Waller in "Du caractère contagieux de la syphilis secondaire," (1850-1851), which gave the account of infecting several children using pus from presumed cases of secondary syphilis.

[7] In a later issue, the 1830s experiments by Dublin's William Wallace and Lourcine's Henri Bouley appeared in an article titled "De la contagion, par voie d'inoculation artificielle, des accidents consécutifs de la syphilis".

[7] A detailed account of how Bouley re-infected a woman with syphilis appeared in the November 1851 issue.