On 28 September 2012, Vitrano and her partner Claudio Casisa formed the comedy duo I Soldi Spicci.
In September 2014, they made their television debut on the Italia 1's comedy show Colorado, and returned for its 2019 edition.
[3] In 2018, the duo made their film debut with a leading role in the La fuitina sbagliata, for which they were also screenwriters.
[5] In September 2020, they began filming their second movie, Un mondo sotto social, where they served as both screenwriters and directors.
[7] In 2024, she was part of the cast of the comedy Succede anche nelle migliori famiglie by Alessandro Siani.