She was born in Bodenham, the daughter of Sir Walter Devereux, the Lord Chancellor of Ireland, and his wife Elizabeth Merbury.
He was the second son of Sir William ap Thomas of Raglan, a member of the Welsh Gentry Family, and his second wife Gwladys ferch Dafydd Gam.
On 8 May 1461, as a loyal supporter of King Edward IV, Herbert was appointed Life Chamberlain of South Wales and steward of Carmarthenshire and Cardiganshire.
With this victory for the House of York came the inmate at Pembroke; the five-year-old nephew of Jasper Tudor, Henry, Earl of Richmond.
Determined to enhance his power and arrange good marriages for his daughters, in March 1462 Anne's husband paid 1,000 for the wardship of Henry Tudor.