Back in the United States, she exhibited, along with other modern artists like Mary Cassatt, Vincent Van Gogh, Edgar Degas, and Claude Monet at the 1913 New York Armory Show.

[2] She was an organizer for the 1915 Exhibition of Painting and Sculpture by Women Artists for the Benefit of the Woman Suffrage Campaign and created works of art for the event.

To lift her spirits, he offered to support her financially for up to ten years if she relocated to New York City to study art.

Goldthwaite arrived in New York around 1898 and enrolled at the National Academy of Design, where she studied etching with Charles Frederick William Mielatz and painting with Walter Shirlaw.

[4][5] In 1906, Anne Goldthwaite traveled to Paris, where she lived at the American Girls' Club and explored her interest in the early modern painting styles of Fauvism and Cubism.

According to Charlotte Rubinstein in American Women Artists, Goldthwaite explained that Stein "looked something like an immense dark brown egg.

She wore, wrapped tight around her, a brown kimono-like garment and a large flat black hat, and stood on feet covered with wide sandals.

But Goldthwaite soon realized Stein's presence in the art world when encountering the extensive contemporary painting collection hung on the walls of her apartment.

[4] Meeting one of the most influential pre-war avant-garde persons of the time gave Goldthwaite an opportunity to join the art circle of Henri Matisse and Pablo Picasso.

She showed The Church on the Hill (1910–11) at the landmark exhibition, alongside renown artists Mary Cassatt, Vincent Van Gogh, Edgar Degas, Claude Monet, and others.

She began painting lovingly rendered portraits of her friends and family, including her sister Lucy, painter Rico Lebrun, and her first New York dealer Joseph Brummer.

Katherine Dreier, a suffragist and cofounder of the organization Société Anonyme, future first lady and Art Students League pupil Ellen Axson Wilson, and portraitist and future director of the Montgomery Museum of Fine Arts Frances Greene Nix were all sitters for Goldthwaite.