For her O-Level and A-Level education, she studied at Bweranyangi Girls' Senior Secondary School in Bushenyi.

She partnered with Brian Mulondo as a Taxi interview conductor in the MiniBuzz series and provided comic video dramatizations of topical issues that random passengers discussed.

[4] According to recorded interviews that she gave in 2014, Anne began posting some of her sketch comedy skits on YouTube.

Her screen breakthrough came when Citizen TV from neighboring Kenya offered her a slot to produce, star and present a comedy show once a week.

She has played to packed houses in Blantyre, Gaborone, Kigali, Kuala Lumpur, Lagos, Lilongwe, London, Lusaka and Harare.

[3] Even amongst various acting commitments, Kansiime has continued performing and touring as a standup comedian.