From 2005 to 2022, she worked at the Albany, New York, office of Boies Schiller Flexner LLP; first as an associate from 2005 to 2012, then as a counsel from 2012 to 2020 and as a partner from 2020 to 2022.

[4] On April 27, 2022, President Joe Biden announced his intent to nominate Nardacci after she had been recommended by U.S.

President Biden nominated Nardacci to the seat vacated by Judge Gary L. Sharpe, who assumed senior status on January 1, 2016.

[7] Nardacci was given a majority "Qualified" rating by the American Bar Association, but was the first judicial nominee by President Biden to receive "Not Qualified" votes from the Standing Committee on the Federal Judiciary.

[9] On November 30, 2022, the United States Senate invoked cloture on her nomination by a 52–45 vote.