Vyskocil earned her undergraduate degree from the Dominican College in Rockland County, New York, where she was the class valedictorian and student government president, and her Juris Doctor from St. John's University School of Law, where she served on the Moot Court Executive Board.

[1] Prior to her appointment to the bench, she practiced general commercial litigation for almost thirty-three years at the New York City-based law firm of Simpson Thacher & Bartlett.

[12] On December 5, 2019, Karen McDougal, an American model and one-time Playboy magazine Playmate who had an affair with Trump in 2006 to 2007, filed a defamation lawsuit against the television network Fox News.

According to the suit, network anchor Tucker Carlson defamed McDougal by saying that she had personally extorted Trump for the hush money she received in 2016, a claim she denied.

[16] Jordan revealed that a "field hearing", in which witnesses would be called, was to be held prior to this, on April 17 at the Jacob K. Javits Federal Building, close to Bragg's office in Manhattan.

[17] At the April 19 district court hearing, Vyskocil ruled that she had no legal standing to block the subpoena and denied Bragg a requested stay of proceedings pending appeal.

"[19] On April 21, Bragg dropped his appeal after reaching an agreement with Jordan that allowed the subpoena against Pomerantz, while protecting the District Attorney's privileges and interests.