She was active in the French Theater of Gustav III in Sweden in 1781-92, and principal of the Royal Dramatic Training Academy jointly with Joseph Sauze Desguillons 1793-98.

Anne Marie Milan Desguillons became a highly valued member of the French theater and was favored by the king.

To her appearance, she was described as heavily overweight and not regarded to be beautiful, but she was much praised for her artistic talent and enjoyed great respect particularly within the court.

The academy had been founded in 1787, but the Desguillons couple was responsible for giving it a proper organisation, which was kept by their successor Sofia Lovisa Gråå.

Among her more known students was Jeanette Wässelius, Sofia Frodelius, Ulrika Wennerholm and Carolina Kuhlman.