Her first husband was Humphrey Stafford, 1st Duke of Buckingham, and she was an important English noblewoman, landholder and book owner during the fifteenth century.
She managed the estates and financial matters with some success: the revenue of her dower lands increased notably under her direction.
Drawing an annual income of £884 in 1460, the year she became a widow, the revenue increased by 40% to £1,245 by 1473, when her grandson Henry Stafford, 2nd Duke of Buckingham came of age.
[2] As the Dowager Duchess of Buckingham she bore the train of queen consort Elizabeth Woodville at her coronation on 26 May 1465.
The two women had exchanged books during the 1460s when Margaret and her husband Humphrey moved close to Anne in Surrey.