[3] Following her mother's death in 1714, her father remarried, his second wife being Lady Rachel Russell, daughter of Wriothesley Russell, 2nd Duke of Bedford; Lady Rachel was about twenty years younger than her husband, and this second marriage produced seven children, who were Anne's half-siblings.

On 22 April 1725, at Ashbridge, Buckinghamshire, Anne married her stepmother's brother, who had succeeded to the dukedom in 1711.

The duke was in financial difficulty, and died on 23 October 1732, aged 24, in Corunna, Spain, and Anne became Dowager Duchess, as the dukedom passed to her husband's brother.

[7] On 7 January 1730 she was the sixth signatory to the Ladies' Petition for the Establishment of the Foundling Hospital, a philanthropic effort organised by Thomas Coram for the protection of infants who would otherwise be a risk of being abandoned.

[8] On 23 June 1733, Anne married William Villiers, 3rd Earl of Jersey, at St. James's, Westminster.