It has a co-educational early learning centre for children between the ages of two and five, and a primary school for reception to year 6.

In 1903, the school was moved to the site of the former Way College for boys on Park Terrace (now Greenhill Road) at Wayville.

In October 2010 Annesley College considered merging with another school due to declining enrolments over the previous seven years.

[13] The Uniting Church stated it would guarantee the continuity of the school for the following two years and that no merger would proceed.

[20] By January 2011, 108 students remained enrolled, down from 466 students mid-2010,[4] and by June 2011 the school announced it would relaunch in 2012 as the Annesley Learning Community, offering a school for boys and girls from Reception to Year 6 (from 2012) and a women's college for Years 10 to 12 (from 2013),[21] with a commensurate drop in staff numbers from 29 to 13.