This stone is still visible at the south-west corner of the original building, now known as the J. F. Ward Wing in honour of the school's first headmaster.

The college began operation in 2 July the following year, with an initial enrolment of 39 boys, and grew steadily in size.

This evolution can be traced through the campus architecture which was first extended in 1925 with the construction of a general classroom block, now the RE Kefford Wing.

A number of new buildings were constructed in the 1930s, including the Headmaster's Residence (now JS Maloney House), a dining hall, extra classrooms and a gymnasium (now the Hamer Wing).

During Collins' 11 years' tenure, construction of the Lych Gate, Memorial Chapel (1960–61), the boat shed, the science block (1956, 1959), additional classrooms (1955, 1963) and the swimming pool (1963) were completed.

During this period, Wesley took a lead role in the introduction of the Achievement Certificate in Western Australia (1969–71) and built the boarding houses of Cygnet and Tranby (1968–70), the HR Trenaman Library (1971), classrooms and balconies around the Jenkins Quadrangle (1972), the Collins Oval (1970) and the Joseph Green Centre (1973–78).

Bednall resigned immediately and a single charge was laid against him which was discontinued in the WA magistrates Court because of a lack of evidence.

The first stage of the school's current masterplan saw the $13 million refurbishment of the Joseph Green Centre as a performing arts and function facility, completed in May 2008.

The second stage saw the refurbishment of the Ward and Kefford Wings of the Senior School ($2m) and the Old Boys' Memorial Chapel ($1.5 million).

The college offers three scholarships a year to indigenous students from rural and regional areas of Western Australia.

As of 2010[update], this has been informally named the "Woodsey Stomp" in recognition of long serving staff member, Frank Woods, who often received this applause every time he was to take the microphone at assembly.

When a well-respected or prominent Wesley teacher retires from the School, a guard of honour is made on the Jenkins Quad.

In 2011 the Wesley College 1st XVIII football team historically won The Alcock Cup breaking a 17-year drought.

The school has a major involvement in the Australian International HPV Super Series, with the program currently being run by Kyal Rees.

Blanckensee Physical Education Centre contains a Hall of Fame showcasing over 160 of Wesley's finest sporting old boys.