Soon after Taxi Driver was cancelled,[4] VanderMeer joined Obsidian Entertainment in January 2006, beginning work on "Project New Jersey" (a rumored unreleased role-playing video game[5]).

[7] While working on Alpha Protocol, VanderMeer assisted with additional design for the first expansion to Neverwinter Nights 2, Mask of the Betrayer.

[13] In January 2018 she joined at System Era Softworks as a content designer on Astroneer,[14] shipping the game and multiple updates before her departure in October 2019.

[17][18] Shortly thereafter, in December 2019, VanderMeer rejoined ArenaNet as a senior game designer for Guild Wars 2,[19] first on their Living World Season "The Icebrood Saga," and later on their third expansion, End of Dragons.

[21] VanderMeer has contributed as a fiction writer to multiple projects at Fantasy Flight Games, including Legend of the Five Rings, The Investigators of Arkham Horror (a fiction collection based on their Arkham Horror franchise),[22] the Twilight Imperium,[23] and Legacy of Dragonholt, a narrative adventure game set in the Runebound universe.