in English[1] at Florida State University in 1997, moving out to Los Angeles to pursue a career writing for television and film.
Shortly thereafter, he was promoted to designer/writer at Black Isle Studios, and took on the role of lead writer for TORN, a PC RPG that used Monolith's Lithtech engine, and a modified version of Fallout's SPECIAL system.
[3] Among the characters that Brian Mitsoda has both written and provided dialogue for in Vampire: The Masquerade – Bloodlines are the ghoul Romero, the elderly hitman Ji Wen Ja, the newscaster and multiple voices on the in-game radio (including one in the infamous "Frickin' Chicken" commercial).
Their first project was Dead State, a turn-based RPG set during a zombie apocalypse developed with the aid of fellow indie game company Iron Tower Studio.
[12] From 2015, Mitsoda worked with Hardsuit Labs on Vampire: The Masquerade – Bloodlines 2 as narrative lead; in July 2020, he and creative director Ka'ai Cluney were terminated from their positions in a joint decision by Hardsuit Labs and the game's publisher Paradox Interactive, which Mitsoda called sudden, unexpected and disappointing.