Annonacin-containing fruit products are regularly consumed throughout the West Indies for their traditional medicine uses.

Use of annonacin products in Guadeloupe often lasts from early childhood through old age, and daily consumption is not uncommon.

[2] It was discovered in Guadeloupe that atypical Parkinsonism was predominant in elderly males, who regularly consume annonacin-containing herbal teas.

[5] Compared to MPP+, annonacin produces a wider and more dramatic loss of neurons, not only in the nigro-striatal system, but in the basal ganglia and brainstem nuclei as well.

[3] Annonacin has been linked to the abnormally high incidence of progressive supranuclear palsy as well as atypical Parkinsonism in the Caribbean island of Guadeloupe where consumption of fruits, such as the soursop (Annona muricata), is common.