Documents from the 14th century reveal that the church was a Jus patronatus founded by Dona Sibila of Aragon.

On November 12, 1372, the chapel was handed over to a Maltese priest Don Bartolommeo Asciach who was probably its second rector.

Up until the Knights Hospitaller's arrival in Malta in 1530, the chapel was mostly administered by the nobility of Aragon and Sicily.

After WWII the chapel was restored extensively and was finally consecrated by the Bishop of Gozo Giuseppe Pace on October 18, 1959.

The chapel has one altar and one titular painting depicting the Annunciation of Jesus, the work of Luca Garnier.