The original building was used as a parochial church for the eastern part of the island of Gozo during the night hours at a time when the only parishes on the island were those of St George and the Collegiate of the Assumption, the present cathedral.

Two other chapels were adjoined to the original church, one dedicated to the Holy Cross and the other to St Mark.

Following the 1551 corsair raid on Gozo, led by Sinam Baxa, the church suffered extensive damage and had to be rebuilt.

It was deconsecrated in 1657 by Bishop Balaguer and a new church was built in its place by order of Grand Master Ramon Despuig.

The church building is listed on the National Inventory of the Cultural Property of the Maltese Islands.