From 1967 to 1974, the church was the seat of the Bishop of the 8th Diocesan District of the Greek Orthodox Archdiocese of North and South America.

Constructed initially at ground level and bound at bottom by a steel tension ring, the dome was crane-lifted as a single piece (138,000 pounds) to its final elevation.

In 1960, the Greek Orthodox Archdiocese of North and South America created archdiocesan districts to better serve the Greek Orthodox faithful throughout the country, and Houston was assigned to the 8th Archdiocesan District, which was served by a bishop in New Orleans, Louisiana.

At that time, the diocese included most of the states in the Great Plains and Rocky Mountain region.

[7] The church in Houston continues to be called a cathedral, however, consistent with the longstanding tradition of many denominations.

These include the Ladies Philoptochos Society; the Cathedral Choir; GOYA (Greek Orthodox Youth of America); FAITH, HOPE and JOY groups (for young children); PAREA (young adults); AGOSS (singles group).

Other ministries, which meet on a regular basis, include marriage preparation and a grief-support group.

The cathedral grounds on Yoakum Boulevard in the Neartown area of Houston are used to host this annual festival.

Proceeds from the Greek Festival are made to various charitable organizations, such as Children's Assessment Center, S.E.A.R.C.H., the Women's Home, Covenant House, Texas Emergency Aid Coalition (EAC), and the Star of Hope Mission.

Basil the Great Greek Orthodox Church on the west side of Houston the first weekend of May every year, except 2020-21.

[12] In the 1990s Houston City Council at large member Joe Roach, who had a son enrolled in the school, promoted having AOS build a new parking lot by buying a block of Marshall Street.

Some area residents opposed on the basis that traffic would increase or that the neighborhood would be physically divided.