[6] The game is set in the near future, where sections of an alien spacecraft have crash-landed in several major cities around the world including Baghdad and Tokyo.

[9] Players control a convoy of vehicles investigating anomalies around sections of a downed alien spacecraft, which are protected by various types of defensive towers that have to be destroyed.

In the Windows, Mac, Linux and XBLA versions, players directly control a soldier on foot (dubbed the Commander) whom they use to pick up and drop the power-ups for the convoy.

GamesBeat gave the game a score of 80/100, saying, "While it's hard to control, Anomaly is still playable and enjoyable as long as you take the time to really master the interface first.".

At the end of 2011 Apple has posted their annual iTunes and App Store rewind lists, where Anomaly: Warzone Earth has been entitled Game Of The Year Runner-Up.