His most high-profile surgery was in 2009 when he worked with a large team of experts to separate the Bangladeshi conjoined twins Trishna and Krishna.
[5] Holmes was part of a large team, including neurosurgeon Wirginia Maixner, involved in the 27 hour surgery to separate the Bangladeshi conjoined twins, Trishna and Krishna who were joined at the skull.
Holmes led an eight-hour operation at the Royal Children's Hospital which removed the tumour and rebuilt Eman's face.
[9] ROMAC also brought Asi from Papua New Guinea so that Holmes and Neurosurgeon Patrick Lo were able to correct a rare cranio-facial abnormality called an encephalocele.
[10] Operation Rainbow and the Australian Filipino Guidance Association raised funds for eight year old Ronald Aguliar to travel to Australia so that surgeons including Holmes could rebuild his severely deformed face.