Skordi wrote, produced and starred in the one-man show Onassis, The Play at the Stella Adler theater to favorable reviews,[2][3] being praised as a "Master of Storytelling".

[4] It was originally planned to bring the play to New York City in 2020, but the theatre production had to be delayed due to the restrictions put into place during the COVID-19 pandemic in the United States.

[6] Though he had been providing narration for commercials[7] and audio books,[8] he was introduced to a new audience through voice acting in video games, his first role being God of War III,[citation needed] alongside other notable actors Kevin Sorbo, Gideon Emery, and Rip Torn.

A short film portraying the Armenian genocide, Straw Dolls features Anthony Skordi in the lead role as Ahmet, a conflicted Turkish soldier.

[citation needed] Skordi portrayed Father Nicolas in Don Quixote, which was featured at the Palm Springs Film Festival in 2015.