Recently, ALS assay nods the scientific community as it is rapidly used for diagnosis of Tuberculosis.
The principle is based on the secretion of antibody from in vivo activated plasma B cells found in blood circulation for a short period of time in response to TB-antigens during active TB infection rather than latent TB infection.
[1] The main advantages are High Sensitivity >93 %, Early detection of active TB.
This method does not require a specimen taken from the site of disease, it also may be useful in diagnosis of paucibacillary childhood TB.
However, if a subject does not show any physical symptoms, the doctors cannot prescribe anti-TB treatment.