Antibodies from lymphocyte secretions

Recently, ALS assay nods the scientific community as it is rapidly used for diagnosis of Tuberculosis.

The principle is based on the secretion of antibody from in vivo activated plasma B cells found in blood circulation for a short period of time in response to TB-antigens during active TB infection rather than latent TB infection.

[1] The main advantages are High Sensitivity >93 %, Early detection of active TB.

This method does not require a specimen taken from the site of disease, it also may be useful in diagnosis of paucibacillary childhood TB.

However, if a subject does not show any physical symptoms, the doctors cannot prescribe anti-TB treatment.