[4] Decreased levels of estrogen can lead to complications in sexual development.

[5] Antiestrogens include selective estrogen receptor modulators (SERMs) like tamoxifen, clomifene, and raloxifene, the ER silent antagonist and selective estrogen receptor degrader (SERD) fulvestrant,[6][7] aromatase inhibitors (AIs) like anastrozole, and antigonadotropins including androgens/anabolic steroids, progestogens, and GnRH analogues.

[8] Although aromatase inhibitors and antigonadotropins can be considered antiestrogens by some definitions, they are often treated as distinct classes.

Antiestrogens act as antagonists of the estrogen receptors, ERα and ERβ.

[13][14] This article incorporates public domain material from Dictionary of Cancer Terms.