Facing criticism from the community for its exaggerated luxury, in the early 18th century it was ceded to the Juanino monks in order to establish the Hospital Real de San José, later known as the Real Hospital de San Juan de Dios.

[2] In 1794 the religious authorities of San Juan de Dios took possession of the hospital.

[2] In 1830, the doctor Juan Manuel González Ureña created the state of Michoacán's first chair of medicine in this building, which led to the creation of the Escuela de Medicina de Michoacán in 1865.

[2] In 1998 its name was changed to Hotel Los Juaninos, in memory of the monks who used it as a hospital.

Inside, the arches surrounding the main patio and on the upper floor are supported by Tuscan-style stonework columns.