The genus belongs to the family Phascolosomatidae.

They are widespread in tropical and subtropical waters.

It has been reported in the western Atlantic and the Caribbean from Florida to Brazil, in the eastern Atlantic in Sierra Leone.

[2][3] Antillesoma antillarum has been found inhabiting mollusc shell middens.

They accompany and associate with the following species of sipunculids: Aspidosiphon albus, A. Parvulus, A. fischeri, Temistes lageniformis, y Nephasoma pellucidum.