Antioch School is a historic building located east of Anamosa, Iowa, United States.

The frame one-room schoolhouse was constructed by local builder Edward M. Harvey in 1872.

American Regionalist artist Grant Wood attended school here from 1896 to 1901.

In 1997, the Jones County Historic Preservation Commission acquired the school building and grounds.

This article about a property in Jones County, Iowa on the National Register of Historic Places is a stub.