Some time before the war of her father against the Romans she married king Ariarathes IV of Cappadocia,[2] who therefore supported his father-in-law in the battle of Magnesia (190 BC).
Antiochis bore her husband a son, who was called Mithridates before his accession to the throne and succeeded his father as Ariarathes V of Cappadocia, and two daughters, among them Stratonice, who first married king Eumenes II of Pergamon and afterwards his brother and successor Attalus II Philadelphus.
According to the questionable report of the ancient Greek-Sicilian historian Diodorus Siculus Antiochis, allegedly an unscrupulous woman, is supposed to have been barren and therefore to have foisted two sons called Ariarathes and Orophernes.
[4] After the death of Ariarathes IV in 163 BC, Antiochis moved back to her birth family's homeland in Antioch, along with her other daughter (whose name is unknown, but not Stratonice).
Polybius blames the death on an assassination by Seleucid regent Lysias, who did not wish to have more nobles of distinguished bloodlines in the city able to oppose him and potentially challenge his authority.