2R9Y534518816ENSG00000167711ENSG00000276838ENSMUSG00000038224P08697Q61247NM_000934NM_001165920NM_001165921NM_008878NP_000925NP_001159392NP_001159393NP_032904Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin.

[5] Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins.

As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis.

This is associated with an increase risk of bleeding in liver disease.