[5][6][7] This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family.

This gene maps outside the epidermal differentiation complex (EDC), a cluster of three gene families involved in epidermal differentiation.

Alternatively spliced transcript variants encoding distinct isoforms have been described.

Autoimmune attack on ECM-1 is responsible for lichen sclerosus.

This article on a gene on human chromosome 1 is a stub.