Antispila isabella is a species of moth of the family Heliozelidae.

It is found in Ontario, Connecticut, Georgia, Kentucky, New York, Pennsylvania and Vermont.

However, research concludes that a complex of species is involved under this name.

They mine the leaves of their host plant.

No gallery is visible and the mine has the form of a large blotch, with a roundish patch of reddish frass near the beginning, probably attached to the upper epidermis, and dispersed black frass throughout the mine.