Froment is best remembered for his role in initiating and solidifying the Reformation in Geneva along with William Farel and John Calvin.
After the people of Geneva had successfully overthrown their prince-bishop, Duke Charles III of Savoy in 1533, Protestant leaders acted swiftly to influence the Genevans to their side.
While in Geneva, Froment founded a school and offered a free education in French reading and writing to anyone who would listen, and used the classroom as a forum for sermons and Romanist criticism.
By that time Calvin and Farel had begun to show feelings of bitter animosity and vexation towards him, and more especially towards his wife Marie.
For the next decade or so, Froment lived as a notary, until in 1561, after marrying a second time following the death of his wife, he was convicted of adultery with a servant and banished for 10 years.